Search on:
VINCA ALKALOIDS
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Vinca Alkaloids
Descriptor
Spanish
:
Alcaloides de la Vinca
Descriptor
Portuguese
:
Alcalóides de Vinca
Tree Number:
D03.132.436.681.827
D03.438.473.402.681.827
Definition
English
:
A group of indole-indoline dimers which are
ALKALOIDS
obtained from the
VINCA
genus of
plants
. They inhibit polymerization of
TUBULIN
into
MICROTUBULES
thus blocking spindle formation and arresting
cells
in
METAPHASE
. They are some of the most useful
ANTINEOPLASTIC AGENTS.
Pharmacological Action:
Antineoplastic Agents
Tubulin Modulators
History Note
English
:
73
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
15153
Unique Identifier:
D014748
Occurrence in VHL
:
Similar:
DeCS
SciELO
LILACS
LIS